Introduction
If you’ve recently discovered you have an MTHFR gene variant, you’re probably wondering whether you should avoid folic acid and whether methylfolate is right for you.
The internet is full of conflicting information. This guide explains the basics in plain English so you can better understand the differences between folic acid and 5-MTHF, and why many people choose bioactive methylfolate.
What is MTHFR?
MTHFR stands for methylenetetrahydrofolate reductase. It’s an enzyme that helps your body convert folate into its active form, called 5-MTHF (5-methyltetrahydrofolate).
Some people inherit genetic variants that may reduce how efficiently this conversion occurs.
Folic Acid vs Folate vs 5-MTHF
These three terms are often confused.
Folate
Folate is the naturally occurring form of vitamin B9 found in foods such as leafy green vegetables, legumes and citrus fruits.
Folic Acid
Folic acid is the synthetic form of vitamin B9 used in many supplements and fortified foods.
Before your body can use it, it must be converted through several steps into active 5-MTHF.
5-MTHF
5-MTHF is the bioactive form of folate that your body can use directly.
Because it’s already in its active form, no further conversion is required.
Why do people choose methylfolate?
Many people prefer supplements containing 5-MTHF because they provide folate in its bioactive form.
Common reasons include:
- Individuals with MTHFR gene variants
- Those wanting an active form of folate
- People seeking high-quality methylation support
- Those looking for premium vitamin B9 supplementation
Is everyone with MTHFR deficient?
No.
Having an MTHFR variant does not automatically mean you are deficient in folate or require supplementation.
If you have health concerns or specific medical conditions, speak with your healthcare professional before making changes to your diet or supplements.
Choosing a methylfolate supplement
When comparing products, consider:
- Bioactive 5-MTHF
- Clearly labelled strength
- Reputable manufacturer
- Australian retailer
- Appropriate dosage for your needs
Triquetra Active L-Methylfolate
At ExoVita Health, we stock the complete Triquetra Active L-Methylfolate range, including:
- Kids L-Methylfolate 1 mg
- Adult L-Methylfolate 1 mg + Methyl B12
- Adult L-Methylfolate 7.5 mg + Methyl B12
- Adult L-Methylfolate 15 mg + Methyl B12
Each formula contains bioactive 5-MTHF, so no conversion is needed.
Frequently Asked Questions
Is methylfolate the same as folic acid?
No. Methylfolate (5-MTHF) is the bioactive form of folate, while folic acid is a synthetic form that requires conversion before the body can use it.
Can everyone take methylfolate?
Dietary supplements aren’t suitable for everyone. If you’re pregnant, breastfeeding, taking medication, or managing a medical condition, seek advice from your healthcare professional before using supplements.
Where can I buy methylfolate in Australia?
ExoVita Health is an authorised Australian retailer of Triquetra Active L-Methylfolate, with fast Australia-wide shipping.
